Efficacy of catheter radiofrequency ablation for the treatment of ventricular arrhythmia storm post cardioverter-defibrillators implantation / 中华心血管病杂志

<p><b>OBJECTIVE</b>To evaluate the acute and long-term effects of catheter radiofrequency ablation for the treatment of ventricular arrhythmia storm (VAS) post implantable cardioverter-defibrillators (ICD) implantation.</p><p><b>METHODS</b>Acute and long-term effects of catheter radiofrequency ablation for the treatment of VAS post ICD implantation were retrospectively assessed in 11 patients from September 2008 to August 2011.</p><p><b>RESULTS</b>A total of 15 ablation procedures were performed in 11 patients. Six ablation procedures were performed through epicardial approach. In 9 patients, 20 types of ventricular tachycardia (VT) (including 20% hemodynamically unstable VT) were induced during the procedures [mean cycle length (384 ± 141) ms] and polymorphic ventricular tachycardia were induced in 7 patients. The average X-ray fluoroscopy time and procedural time were (26 ± 17) min and (189 ± 60) min, respectively. Complete success, partial success, and failure rates immediately post catheter radiofrequency ablation were 46.7% (7/15), 26.7% (4/15) and 26.7% (4/15), respectively. All patients are alive at follow-up[(2.45 ± 9.6) months after the last catheter ablation] and the complete success, partial success, and failure rates during follow-up were 72.7% (8/11), 9.1% (1/11) and 18.2% (2/11), respectively.</p><p><b>CONCLUSION</b>VAS can be effectively treated by catheter radiofrequency ablation in patients post ICD implantation.</p>

Catheter ablation of focal atrial tachycardia:the topographic distribution and long-term outcome / 中华心血管病杂志

<p><b>OBJECTIVE</b>To explore the topographic distribution and long-term outcome of catheter ablation for focal atrial tachycardia (AT).</p><p><b>METHOD</b>The data of 207 patients who underwent electrophysiologic study for AT were retrospectively analyzed.</p><p><b>RESULTS</b>A total of 200 AT were identified in 185 patients. The most common site for AT was ostium of the coronary sinus (23.8%), followed by crista terminalis (20.5%), perinodal area (20.0%), cava vena (17.8%), annulus (13.0%), and appendage (10.3%). Eighty percent AT originated from the right atrium, 17.8% originated from the left atrium. AT originated from the left atrium was more common in male than in female (25.0% vs. 13.3%, P = 0.042), while AT originated from the right atrium was more common in female than in male (69.4% vs. 86.7%, P = 0.004). Among the 185 patients, acute success ablation rate was 93.5% (n = 173). The acute success rate in the conventional mapping group was lower than that in the three-dimensional mapping group (79.3% vs. 96.5%, P < 0.01). During a median of 36 months follow up, the AT recurred in 20 patients (success ablation rate 88.4%). Success ablation rate was similar between the conventional mapping group and the three-dimensional mapping group (P > 0.05).</p><p><b>CONCLUSIONS</b>Focal AT commonly originates from ostium of coronary sinus, crystal terminalis, perinodal area, and cava veins. There is a gender related difference in the distribution of focal AT. The radiofrequency catheter ablation yields a satisfying success rate and very low complication rate and could be the first line choice for treating ATs in experienced electrophysiological center.</p>

The Anti-oxidation Activity and Liver Damage Induced by Chronic Fluorosis in Male Rats / 环境与健康杂志

Objective To know the relationship between the changes of total anti-oxidation capacity (T-AOC),nitric oxide (NO) and nitric oxide synthase (NOS) the liver and liver damage induced by chronic fluoride exposure.Methods Eighteen male Wistar rats were randomly divided into 3 groups,control(treated with tap water),low fluoride(LF,treated with NaF at 100 mg/L) and high fluoride (HF,treated with NaF at 200 mg/L),6 in each group.Fluoride was given through drinking water.During the period of exposure,the body was weighed and after 6 months of treatment,the rats were killed,the liver coefficient was calculated,T-AOC, NO and NOS in the livers were determined respectively.Results Compared with the control,the liver coefficient,NO and NOS in the fluoride treated groups significantly increased (P

The more efficacious acupoints of Zusanli and Sanyinjiao than that of non-acupoints on bone mass in osteopenic ovariectomized rats / 中国结合医学杂志

<p><b>OBJECTIVE</b>To clarify whether the acupoints of Zusanli (ST36) and Sanyinjiao (SP6) have specific actions other than non-acupoints to bone.</p><p><b>METHODS</b>Forty Sprague-Dawley female rats were divided into five groups: Sham operated (sham) group; Ovariectomized (OVX, model) group; non-acupuncture group; OVX, needling on Zusanli and Sanyinjiao (Acp-A) group; OVX, needling on the reverse sides of Zusanli and Sanyinjiao (Acp-B) group; OVX, periostineal stimulation on the same height as points of Zusanli and Sanyinjiao (Acp-C) group. The experiment was continued for 23 weeks and then all animals were sacrificed.</p><p><b>RESULTS</b>OVX had a significantly higher body weight and lower bone mineral density (BMD) on the lumbar vertebrae, total femora and tibiae than sham rats, however, Acp-A showed a higher BMD compared with the other OVX groups. On the other hand, bone weights, bone strength and bone morphometry such as trabecular volume, trabecular separation, labeled width and bone formation rate also showed the same improvements in Acp-A as compared to the other OVX rats.</p><p><b>CONCLUSION</b>The stimulation on Zusanli and Sanyinjiao specifically prevented the development of osteopenic rats compared with non-acupoints.</p>

Analysis of the effectiveness of laser in situ keratomileusis two years after surgery / 中国医学科学院学报

<p><b>OBJECTIVE</b>To evaluate the effectiveness of laser in situ keratomileusis (LASIK) for myopia after 2 year follow-up.</p><p><b>METHODS</b>LASIK surgery was performed for 95 eyes (49 cases) with refractive dioptres (from -1.00 to -16.50 D), and then followed up for more than 2 years. The preoperative spherical equivalent was -1.00(-)-16.50 (-6.73 +/- 2.02) D. Patients were divided into two groups including group I with mild to moderate myopia (< or = -6.00 D) and Group II with severe myopia (more than -6.00 D).</p><p><b>RESULTS</b>In group I, uncorrected visual acuity more than and equivalent to 1.0 was in 40 eyes (93.02%), more than and equivalent to 0.8 in 43 eyes (100%). In group II, uncorrected visual acuity larger than and same as 1.0 was in 37 eyes (71.15%), larger than and same as 0.8 in 45 eyes (86.54%), larger than and same as 0.5 in 50 eyes (96.15%), and less than 0.5 in 2 eyes (3.85%). The mean spherical equivalent changed from (-4.14 +/- 0.86) D to (-0.04 +/- 0.14) D in group I and from (-9.00 +/- 1.64) D to (-0.08 +/- 0.20) D in group II. Significant difference was seen in these two groups (P < 0.001). The keratometric powers (K) were reduced from (44.31 +/- 0.78) to (40.11 +/- 1.23) and from (45.46 +/- 1.00) to (38.01 +/- 1.73) respectively, which showed significant difference (P < 0.001).</p><p><b>CONCLUSION</b>The effectiveness of LASIK for mild to moderate myopia or severe myopia is promising and safe.</p>

Static and dynamic contrast sensitivity of myopic eyes before and after laser in situ keratomileusis / 中国医学科学院学报

<p><b>OBJECTIVE</b>To evaluate the static and dynamic contrast sensitivity changes in myopic patients before and after laser in situ keratomileusis (LASIK).</p><p><b>METHODS</b>Seventy-three eyes in 37 patients with myopia (with or without astigmatism) who received LASIK were tested for static and dynamic contrast sensitivities using the METRO VISION MON ELEC I system at 0.7, 1.4, 2.7, 5.5, 11, and 22 cpd and cps prior to LASIK, and at one-, three-, and six-month intervals after LASIK.</p><p><b>RESULTS</b>All eyes gained naked visual acuity of more than 0.5 after LASIK. The contrast sensitivity was depressed at all frequencies 1 month after LASIK, as compared to one week prior to LASIK. The depression at 2.7, 5.5, 11 (P < 0.01) and 22 cpd (P < 0.05) was statistically significant for static contrast sensitivity, and also at 5.5 (P < 0.01) and 11 cps (P < 0.05) for dynamic contrast sensitivity. Myopic eyes between 6.25 D and 14.0 D, and astigmatic eyes 2 DC and more, suffered more static and dynamic contrast sensitivity depression than the myopic eyes between 1.25 D and 6.00 D and astigmatic eyes less than 2 DC. Contrast sensitivities were improved and exceeded preoperative levels 3 months after LASIK, and improved even more 6 months after LASIK. All sequences were statistically significant for static contrast sensitivity (P < 0.01), while only 2.7, 5.5, and 11 cps were statistically significant for dynamic contrast sensitivity (P < 0.01). The astigmatic eyes 2 DC and more showed less improvement, even below the preoperative level at 1.4 cps of dynamic contrast sensitivity.</p><p><b>CONCLUSIONS</b>While temporary depression of contrast sensitivity for myopic eyes after LASIK was seen, contrast sensitivity soon returned to exceed preoperative levels at 3 months after LASIK, while improving even more 6 months after LASIK.</p>

Bilateral symmetry of corneal topography / 眼科

Objective To compare the bilateral symmetry characters of corneal topography in patients with different refraction, age and gender.Design Retrospective case series.Participants 1000 eyes of 500 patients who were going to undergo corneal refractive surgery with myopia from 18 to 47 years old.Methods Bilateral corneal topography was obtained using TOMEY Version 3.30.Contact lenses had not been worn for more than a week before the examination,and patients with dry eye or other ocular and systemic diseases were excluded.Main Outcome Measures Symmetry and symmetric rates of corneal topography.Results Bilateral symmetry of loca- tion of the cone apex and refraction:uniform 3.4%;almost symmetry 1.8%;approximately symmetry 79.0%;asymmetry 15.8%.The rates of bilateral symmetry in patients with different refraction:0.05).Conclusions 80% of patients with myopia have bi- lateral symmetric corneal topography patterns.The rates of bilateral symmetry of corneal topography increase with the increase of spher- ical refraction(